BMS 625 - Biochemistry

Course Overview

This course is part of the foundations class and will survey selected advanced aspects of basic biochemistry that are both fundamental and relevant to GSBSE areas of investigational focus. Generally, this class will cover central principles of macromolecular structure and catalysis, intermediary metabolism, and aspects of macromolecular information flow (e.g., signaling).

Students will participate in class discussion or a research paper highlighting the topic at hand. Generally, the students will confer amongst themselves to provide an introduction/overview of the paper on hand, then split up presentation of the results by data figures, and then a summary, followed by further discussion by all. (Depending on the number of attendees, we may alternate responsibility for conducting the paper presentation to preassigned teams. However, in this case, everyone is still expected to participate in the overall discussion.)

This class is offered in the Spring.

Topics Covered

  • Protein and enzyme pH behavior); protein tertiary and quaternary structures
  • Enzymes 
  • Biosignaling: Receptor tyrosine kinases
  • Intermediary metabolism I-Glycolysis
  • Intermediary metabolism II-Gluconeogenesis, Pentose phosphate shunt
  • Lipids
  • Principles of Metabolic regulation-I Thermogenesis
  • Principles of metabolic regulation-II
  • Fatty acid catabolism
  • Lipid biosynthesis
  • Metabolic integration: tissues, hormones, and obesity
  • Protein synthesis
  • Targeting and degradation
  • Regulation of gene expression in eukaryotes
  • RNA-mediated gene regulation
  • Developmental cascades



Bob Gundersen