Stress Response and Adaptation
The biology of stress involves the responses and adaptations of a cell or organism to external challenges and is one of the most striking characteristics of all live systems. GSBSE faculty are examining the effects of stress at the translational level in the areas of post-traumatic stress disorder, anxiety, stress hormones, and the effects of toxicants. At the cellular and molecular level, researchers are studying mitochondrial response, signaling pathways, changes in immunity that include T lymphocytes and the central nervous system, chromosomal instability, and altered development. Another area of study is nutrient restriction and changes to post-transcriptional gene expression. Disease states and their interactions induced by stress are also being studied and include obesity and perivascular adipose tissue vascular interactions, obesity and cardiovascular health, and effects on angiogenesis and the extracellular matrix.