Ph.D. Duke University 2010
I explore the genetic variation segregating within natural populations to discover how common or rare alleles that assert subtle individual effects act in combination to disrupt the normal network state and confer genetic susceptibility to developmental anomalies, adult disorder, and disease. I have established the bipotential embryonic mouse gonad at the critical stage of primary sex determination as an ideal mammalian model of cell differentiation and organogenesis that is particularly amenable to systems genetic approaches. My research strategy integrates experimental and computational methods to infer and test predictive transcription network models governing sex determination in a population of genetically diverse mice. I have extensive interdisciplinary training in developmental biology, complex trait genetics, genomics, and bioinformatics. I value and promote a collaborative research environment. I have a strong passion for education, and extensive experience teaching and mentoring high school through graduate-level students.