Mary Teena Joy

Education: 

  • University College London (UCL), U.K., Ph.D., Neuroscience
  • VIT University, India, M.Sc., Biomedical Genetics
  • Fatima Mata National College (Kerala University), India, B.Sc., Biotechnology

Brief Biography:

I received my PhD in Neuroscience from University College London (UCL) where I trained with Dr. Patrick Anderson. My work focused on understanding molecular mechanisms that can be targeted for axonal regeneration in the injured spinal cord. Towards the end of my PhD, I became interested in projections upstream of the spinal cord, in the brain, where connections are more plastic. To further my understanding in reparative mechanisms in the brain, I undertook postdoctoral training with Dr. S.Thomas Carmichael at UCLA, where I studied molecular mechanisms that underlie plasticity during learning and memory as targets for stroke. In addition to molecular targets, I became interested in how neural circuits interact during movement, a domain that is compromised in stroke patients. For further training, I was awarded a visiting fellowship at Janelia, HHMI, where I worked with Dr. Adam Hantman, where I used a unique imaging platform to visualize and target circuit activity across multiple regions in the brain to determine how motor information is encoded in real-time in the normal brain. In my current lab, using a combination of techniques, we will determine how circuits re-organize after a stroke, how these re-organizational processes contribute to changes in motor function, molecular mechanisms that enhance plasticity in these circuits and therapeutic targets that can be clinically translated.

Publications:

  • Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke. Campos B., Choi H., DeMarco A., Seydell-Greenwald A., Hussain S., Joy M T, Turkeltaub P E, Zeiger W (2023) J. Neurosci. In press. (invited review, all authors contributed equally)
  • Activity-dependent Transcriptional Programs in Memory Regulate Motor Recovery after Stroke. Joy M T, Carmichael S T. (manuscript under review) 
  • Encouraging an excitable brain state: mechanisms of brain repair in stroke. Joy M T and Carmichael ST (2021). Nat Rev Neuroscience, 22, 38–53. 
  • Learning and stroke recovery: parallelism of biological substrates. Joy M T and Carmichael S T (2021). Semin Neurol. 41(2):147-156.
  • Chemokine receptors CCR5 and CXCR4 are new therapeutic targets for brain recovery following Traumatic
    Brain Injury. Liraz Zaltsman S., Friedman-Levi Y., Shabashov-Stone D, Gincberg G, Atrakcy-Baranes D, Joy M T.,
    Carmichael S T, Silva A, Shohami E (2021): J. Neurotrauma, 15;38(14):2003-2017.
  • CCR5 is a therapeutic target to stimulate recovery in stroke and traumatic brain injury.
    Joy M T, Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Thareja NS, Arenas M, Kilper E, Korczyn AD,
    Kesner E, Zhou M,Huang S, Silva T, Katz N, Bornstein N, Silva AJ, Shohami E, Carmichael ST (2019) Cell,
    176(5),1143-1157.
    Featured in:
    The Lancet Neurology: Recovery from brain injury: a surprising new drug target; Rosand, J., et. al. (2019).
    Nature Reviews Drug Discovery: Repurposing CCR5 inhibitors for stroke recovery; Villanueva, M.T. (2019)
    Science: HIV drug could improve recovery after stroke, Servick K. (2019)
  • Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and
    aggregation. Hayden EY; Putman J; Nunez S; Shin WS ; Oberoi M; Charreton M; Dutta S; Li Z; Komuro Y; Joy M T; Bitan G; MacKenzie-Graham A; Jiang L; Hinman JD (2019): Acta Neuropathologica Communications;
    20;7(1):135.

For more publications, please visit Google Scholar profile: https://scholar.google.com/citations?hl=en&user=tK-JcTwAAAAJ