Lucas Chang


  • D.Phil. (Ph.D.), University of Oxford, 2010

Research Interests

Metabolism is a set of biochemical transformations, which remains the single most fundamental force driving cell fate and sustaining life. Our lab is particularly interested in understanding the cellular and molecular mechanisms that control immune cell behavior during disease development. Our investigation is currently focused on elucidating the metabolic events involved in T cell reprogramming in tumor microenvironment. Our research lies at the intersection of immunology, metabolism, microbiology, oncology, pharmacology, and bioinformatics. Ultimately, our goal is to provide detailed mechanistic understanding of metabolic interplay between immune cells and diseased tissues, which will offer novel strategies for vaccines, drug development, disease prognosis, and immunotherapy.

Selected Publications

  • Chang CH, Pearce EL. (2016) Emerging concepts of T cell metabolism as a target for immunotherapy. Nature Immunology, 17(4):364-368.
  • Chang CH, Qiu J, O’Sullivan D, Buck MD, Noguchi T, Curtis JD, Gindin M, Chen Q, Gubin MM, Tonc E, van der Windt GJ, Schreiber RD, Pearce EJ, Pearce EL. (2015) Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell, 162(6):1229-41.

Full List of Publications