- M.D., Clinical Medicine, Beijing Medical University (Currently Peking University Health Science Center), 1997
- Ph.D., Toxicology, SUNY Albany, 2002
Dr. Cao has had successful training in both clinical medicine (Beijing Medical University, MD, 1997) and biomedical research (SUNY at Albany, PhD, 2002, followed by Post-Doctoral training at the University of Rochester Medical Center and Dartmouth Medical College). Through these training, she has obtained good understanding of clinical needs and is well-equipped with necessary skills for the investigation of clinical-relevant biomedical questions. As an independent researcher, her goal is to continue advanced biomedical/translational research, help to bridge basic scientific findings into clinic therapeutic use, as well as mentor students pursuing a career in clinical medicine and/or biomedical research. Dr. Cao’s research focuses on the understanding of interactions between the nervous system and the immune system. Specific areas of interest include: 1) The roles of CNS infiltrating T lymphocytes, macrophages and resident microglia in the pathophysiology of neurological diseases induced by trauma, infection or toxic agents; 2) Effects of neurotransmitters, neuropeptides, and stress hormones on immune functions, particularly host defense towards infectious diseases. In the Cao lab, current investigations are focusing on two NIH-funded projects: 1) the role of co-stimulatory molecule, CD137 ligand (41BBL) in the development of neuropathic pain and nerve recovery and regeneration following peripheral nerve injury, and 2) Therapeutic potential of interferon (IFN)-beta for HIV-associated neurological disorders in opioid users.
- J. Malon and L. Cao. 2016. Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways. Journal of Neuroimmunology 297,68-75. (PMCID: PMC4940993)
- J. Malon and L. Cao. 2016. Preparation of primary mixed glial cultures from adult mouse spinal cord tissue. Journal of Visulized Experiments. Nov 19;(117). doi: 10.3791/54801. (PMCID: PMC5153361)
- V. D. McLane, I. Bergquist, J. Cormier, D.J. Barlow, K.L. Houseknecht, E. J. Bilsky, L. Cao. 2017. Long-term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone-precipitated withdrawal. Life Sciences. Sep 15;185:1-7. doi: 10.1016/j.lfs.2017.
- J. G. Kimball, L. Cao, and K. S. Draleau. 2017. Efficacy of the Wilbarger Therapressure Program™ to Modulate Arousal in Women with Post-Traumatic Stress Disorder (PTSD): A Pilot Study Using Salivary Cortisol and Behavioral Measures. Occupational Therapy in Mental Health. doi: 10.1080/0164212X.2017.1376243.
- L. Cao, F.Y. Tanga and J. A. DeLeo. 2009. The contributing role of CD14 in Toll-Like receptor 4 dependent neuropathic pain. Neuroscience 158(2), 896-903.
- L. Cao, C. D. Palmer, J. T. Malon and J. A. DeLeo. 2009. Critical role of microglial CD40 in the maintenance of mechanical hypersensitivityin a murine model of neuropathic pain. European Journal of Immunology (Epub ahead of print, DOI: 10.1002/eji.200939657)
- L. Cao and J. A. DeLeo. 2008. CNS infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. European Journal of Immunology 38, 448-458 (featured “In This Issue”).
- C. A. Hudson, G. P. Christophi, L. Cao, R. C. Gruber and P. T. Massa. 2007. Regulation of avoidant behaviors and pain by the anti-inflammatory tyrosine phosphatase SHP-1. Neuron Glia Biology 2 (4), 235-246.
- L. Cao, C. A. Hudson, and J. A. Moynihan. 2007. Chronic foot shock induced hyperactive behaviors in mice: involvement of both pro- and anti- inflammatory mediators. Journal of Neuroimmunology 186(1-2), 63-74
- L. Cao, L. Fei, T. T. Chang, and J. A. DeLeo. 2007. Further induction of IL-1beta by IL-4 in LPS-treated mixed glial cultures. Journal of Neurochemistry 102(2), 408-419.
- C. A. Hudson, T. K. Modal, L. Cao, J. Kasten-Jolly, V. C. Huber, and D. A. Lawrence. 2005. The dietary supplement ephedrine induces b-adrenergic mediated exacerbation of systemic lupus erythematosus in NZM391 mice. Lupus 14, 293-307.
- L. Cao, A. Martin, N. Polakos, and J. A. Moynihan. 2004. Stress causes a further decrease in immunity to herpes simplex virus-1 in immunocompromised hosts. Journal of Neuroimmunology 156, 21-30.