Julie Gosse

Education

  • Ph.D., Cornell University, 2005

Research Interests

Biochemical, molecular, biophysical, and cellular toxicology.  Effects of toxicants on signal transduction pathways and mitochondria.

Selected Publications

  • “Pharmaceutical Agent Cetylpyridinium Chloride Inhibits Immune Mast Cell Function by Interfering with Calcium Mobilization,” Bright Obeng, Christian M. Potts, John E. Burnell, Bailey E. West, Patrick J. Fleming, Juyoung K. Shim, Marissa S. Kinney, Alan Y. Baez Vasquez, Marissa Paine, Suraj Sangroula, Collin Frangos, Lucas Bennett, Dylan J. Wagner, Julie A. Gosse, in preparation
  • “Mechanisms of Antimicrobial Agent Cetylpyridinium Chloride Mitochondrial Toxicity in Rodent and Primary Human Cells: Super-resolution Microscopy Reveals Nanostructural Disruption,” Sasha R. Weller, John E. Burnell, Brandon M. Aho, Bright Obeng, Emily L. Ledue, Juyoung K. Shim, Samuel T. Hess, Julie A. Gosse; bioRxiv 2022.09.27.509813; doi: https://doi.org/10.1101/2022.09.27.509813
  • “Phosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane,” Raut P, Obeng B, Waters H, Zimmerberg J, Gosse JA, Hess ST.  Viruses. 2022 Nov 12;14(11):2509. doi: 10.3390/v14112509. PMID: 36423118; PMCID: PMC9698905.
  • “Localization-Based Super-Resolution Microscopy Reveals Relationship between SARS-CoV2 Spike and Phosphatidylinositol (4,5)-bisphosphate,” Prakash Raut, Hang Waters, Joshua Zimmberberg, Bright Obeng, Julie Gosse, and Samuel T. Hess, Proc. of SPIE, 2022, vol. 11965, 1196503, 1605-7422, doi: 10.1117/12.2613460.
  • “Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function,” Prakash Raut, Sasha R. Weller, Bright Obeng, Brandy L. Soos, Bailey E. West, Christian M. Potts, Suraj Sangroula, Marissa S. Kinney, John E. Burnell, Benjamin L. King, Julie A. Gosse, Samuel T. Hess; Toxicology and Applied Pharmacology,2022, in press
  • “Triclosan Disrupts Immune Cell Function by Depressing Ca2+Influx Following Acidification of the Cytoplasm,” Suraj Sangroula, Alan Y. Baez Vasquez, Prakash Raut, Bright Obeng, Juyoung K. Shim, Grace D. Bagley, Bailey E. West, John E. Burnell, Marissa S. Kinney, Christian M. Potts, Sasha R. Weller, Joshua B. Kelley, Samuel T. Hess, Julie A. Gosse; Toxicology and Applied Pharmacology, 2020, vol. 405, p 115205.  doi:  10.1016/j.taap.2020.115205.
  • Antimicrobial Agent Triclosan Suppresses Mast Cell Signaling via Phospholipase D Inhibition; Juyoung K. Shim, Molly A. Caron, Lisa M. Weatherly, Logan B. Gerchman, Suraj Sangroula, Siham Hattab, Alan Y. Baez, Talya J. Briana, Julie A. Gosse;Journal of Applied Toxicology, 2019, vol. 39, pp. 1672-1690.  doi:  10.1002/jat.3884.
  • Maternal responsivity and oxytocin in opioid dependent mothers; Katrina M. Daigle, Nicole A. Heller, Ella J. Sulinski, Juyoung Shim, William Lindblad, Julie A. Gosse, Marie J. Hayes; Developmental Psychobiology, 2020, vol. 62, pp. 21-35.  doi:  10.1002/dev.21897.
  • Searching for Tryptase in the RBL-2H3 Mast Cell Model:  Preparation for Comparative Mast Cell Toxicology Studies with Zebrafish; Juyoung K. Shim, Rachel H. Kennedy, Lisa M. Weatherly, Andrew V. Abovian, Hina N. Hashmi, Atefeh Rajaei, Julie A. Gosse; 2019,  J Appl Toxicol.;39:473-484. doi: 10.1002/jat.3738.
  • “Antimicrobial Agent Triclosan Disrupts Mitochondrial Structure, Revealed by Super-resolution Microscopy, and Inhibits Mast Cell Signaling via Calcium Modulation,” Lisa M.Weatherly, Andrew J. Nelson, Juyoung Shim, Abigail M. Riitano, Erik D. Gerson, Andrew J. Hart, Jaime de Juan-Sanz, Timothy A. Ryan, Roger Sher, Samuel T. Hess, Julie A. Gosse, Toxicol Appl Pharmacol. 2018 Jun 15;349:39-54. doi: 10.1016/j.taap.2018.04.005.
  • “Elevated nitrate alters the metabolic activity of embryonic zebrafish,” Conlin SM, Tudor MS, Shim J, Gosse JA, Neilson A, Hamlin HJ, 2017, Environ Pollut.; 235:180-185. doi: 10.1016/j.envpol.2017.12.069.
  • “Triclosan Exposure, Transformation, and Human Health Effects,” Lisa M. Weatherly and Julie A. Gosse, 2017, J Toxicol Environ Health B Crit Rev.; 20(8):447-469. doi: 10.1080/10937404.2017.1399306.
  • “Triclosan is a Mitochondrial Uncoupler in Live Zebrafish,” Juyoung Shim, Lisa M. Weatherly, Richard H. Luc, Maxwell T. Dorman, Andy Neilson, Ryan Ng, Carol H. Kim, Paul J. Millard, Julie A. Gosse, 2016, Journal of Applied Toxicology, doi: 10.1002/jat.3311
  • “Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events,” Juyoung Shim*, Rachel H. Kennedy*, Lisa M. Weatherly, Lee M. Hutchinson, Jonathan H. Pelletier, Hina N. Hashmi, Kayla Blais, Alejandro Velez, Julie A. Gosse (*contributed equally), 2016, Journal of Applied Toxicology, doi: 10.1002/jat.3300
  • “Antimicrobial Agent Triclosan is a Proton Ionophore Uncoupler of Mitochondria in Living Rat and Human Mast Cells and in Primary Human Keratinocytes,” Lisa M. Weatherly, Juyoung Shim, Hina N. Hashmi, Rachel H. Kennedy, Samuel T. Hess, and Julie A. Gosse, in press, Journal of Applied Toxicology
  • “Monomethylated Trivalent Arsenic Species Disrupt Steroid Receptor Interactions with their DNA Response Elements at Non-cytotoxic Cellular Concentrations,” Julie A. Gosse, Vivien F. Taylor, Brian P. Jackson, Joshua W. Hamilton, and Jack E. Bodwell, Journal of Applied Toxicology, 2013, doi: 10.1002/jat.2898
  • “Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study,” Dennis Liang Fei, Devin C. Koestler, Zhigang Li, Camilla Giambelli, Avencia Sanchez-Mejias, Julie A. Gosse, Carmen J. Marsit, Margaret R. Karagas, and David J. Robbins, Environmental Health, 2013, vol. 12, p. 58.
  • “A Microplate Assay to Assess Chemical Effects of RBL-2H3 Mast Cell Degranulation: Effects of Triclosan Without Use of an Organic Solvent,” Lisa M. Weatherly, Rachel H. Kennedy, Juyoung Shim, and Julie A. Gosse*, Journal of Visualized Experiments, 2013, vol. 81, e50671, doi:10.3791/50671. *corresponding author.
  • “Actin Mediates the Nanoscale Membrane Organization of the Clustered Membrane Protein Influenza Hemagglutinin,” Manasa V. Gudheti, Nikki M. Curthoys, Travis J. Gould, Dahan Kim, Mudalige S. Gunewardene, Kristin A. Gabor, Julie A. Gosse, Carol H. Kim, Joshua Zimmerberg, and Samuel T. Hess, Biophysical Journal, 2013, vol. 104, pp. 2182-2192.
  • “Visualizing the molecular timing of a physiological decision at the nanoscale,” Samuel T. Hess* and Julie A. Gosse*, Biophysical Journal, 2013, vol. 105, pp. 2617-8. *co-corresponding authors.
  • Antibacterial agent triclosan suppresses RBL-2H3 mast cell function, Rachel K. Palmer, Lee M. Hutchinson, Benjamin T. Burpee, Emily J. Tupper, Jonathan H. Pelletier, Zsolt Kormendy, Alex R. Hopke, Ethan T. Malay, Brieana L. Evans, Alejandro Velez, Julie A. Gosse*, Toxicology and Applied Pharmacology, vol. 258, 2012, pp. 99-108. *corresponding author.
  • Estrogen mimetic 4-tert-octylphenol enhances IgE-mediated degranulation of RBL-2H3 mast cells, Rachel H. Kennedy, Jonathan H. Pelletier, Emily J. Tupper, Lee M. Hutchinson, and Julie A. Gosse*, Journal of Toxicology and Environmental Health, Part A, vol. 75, 2012, pp. 1451-1455. *corresponding author.
  • Inorganic Arsenite Inhibits IgE Receptor-Mediated Degranulation of Mast Cells, Lee M. Hutchinson, Benett M. Trinh, Rachel K. Palmer, Christopher A. Preziosi, Jonathan H. Pelletier, Hannah M. Nelson, Julie A. Gosse*, Journal of Applied Toxicology, vol. 31, 2011, pp. 231-241. *corresponding author.
  • Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors, Dennis Liang Fei, Hua Li, Courtney D. Kozul, Kendall E. Black, Samer Singh, Julie A. Gosse, James DiRenzo, Kathleen A. Martin, Baolin Wang, Joshua W. Hamilton, Margaret R. Karagas, and David J. Robbins, Cancer Research, vol. 70, 2010, pp. 1981-8.
  • Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung, Courtney D. Kozul, Thomas H. Hampton, Jennifer C. Davey, Julie A. Gosse, Athena P. Nomikos, Phillip L. Eisenhauer, Daniel J. Weiss, Jessica E. Thorpe, Michael A. Ihnat, Joshua W. Hamilton, Environmental Health Perspectives, vol. 117, 2009, pp. 1108-1115
  • A new approach to analysis and interpretation of toxicogenomic gene expression data and its importance in examining biological responses to low, environmentally-relevant doses of toxicants, Julie A. Gosse, Thomas H. Hampton, Jennifer C. Davey, Joshua W. Hamilton, in book entitled Toxicogenomics: A powerful tool for toxicity assessment, edited by Saura C. Sahu, John Wiley & Sons Ltd., Oct. 2008, pp. 27-57.
  • Laboratory Diet Profoundly Alters Gene Expression and Confounds Genomic Analysis in Mouse Liver and Lung, Courtney D. Kozul, Athena P. Nomikos, Thomas H. Hampton, Linda A. Warnke, Julie A. Gosse, Jennifer C. Davey, Jessica E. Thorpe, Brian P. Jackson, Michael A. Ihnat, Joshua W. Hamilton, Chemico-Biological Interactions, vol. 173, 2008, p. 129-140.
  • Nanoscale imaging of molecular positions and anisotropies, Travis J. Gould, Mudalige S. Gunewardene, Manasa V. Gudheti, Vladislav V. Verkhusha, Shu-Rong Yin, Julie A. Gosse, Samuel T. Hess, Nature Methods, vol. 5, 2008, pp. 1027-30.
  • Arsenic as an endocrine disruptor: Effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture, Jennifer C. Davey, Jack E. Bodwell, Julie A. Gosse, Joshua W. Hamilton, Toxicological Sciences, vol. 98, 2007, pp. 75-86.
  • Arsenic disruption of steriod receptor gene activation: Complex dose-response effects are shared by several steroid receptors, Jack E. Bodwell, Julie A. Gosse, Athena P. Nomikos, Joshua W. Hamilton, Chemical Research in Toxicology, vol. 19, issue 12, 2006, pp. 1619-29.
  • Transmembrane sequences are determinants of immunoreceptor signaling, Julie A. Gosse, Alice Wagenknecht-Wiesner, David Holowka, Barbara Baird, The Journal of Immunology, vol. 175, 2005, pp. 2123-31.
  • Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells, Daniel R. Larson*, Julie A. Gosse*, David A. Holowka, Barbara A. Baird, Watt W. Webb (*First two authors contributed equally to this work), The Journal of Cell Biology, vol. 171, 2005, pp. 527-36.
  • Lipid segregation and IgE receptor signaling: A decade of progress, David Holowka, Julie A. Gosse, Adam T. Hammond, Xuemei Han, Prabuddha Sengupta, Norah L. Smith, Alice Wagenknecht-Wiesner, Min Wu, Ryan M. Young, Barbara Baird, Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1746, 2005, pp. 252-9.

Dissertation Students

https://gsbse.umaine.edu/people/sasha-weller/

Students

  • Chair of the Ph.D. committee for Lisa Weatherly, GSBSE, 2012-2017, defended successfully 4-14-17.  Went to a Research Associate position at CDC-NIOSH
  • Chair of the Ph.D. committee for Rachel Kennedy (formerly Palmer), GSBSE, 2009-2013, defended successfully on 6-17-13.  Went to a postdoctoral position at Columbia University