Julie Gosse


Ph.D. (2005) Cornell University

Research Interests

Biochemical, molecular, biophysical, and cellular toxicology.  Effects of toxicants on signal transduction pathways and mitochondria.

Selected Publications

  • “Triclosan is a Mitochondrial Uncoupler in Live Zebrafish,” Juyoung Shim, Lisa M. Weatherly, Richard H. Luc, Maxwell T. Dorman, Andy Neilson, Ryan Ng, Carol H. Kim, Paul J. Millard, Julie A. Gosse, 2016, Journal of Applied Toxicology, doi: 10.1002/jat.3311
  • “Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events,” Juyoung Shim*, Rachel H. Kennedy*, Lisa M. Weatherly, Lee M. Hutchinson, Jonathan H. Pelletier, Hina N. Hashmi, Kayla Blais, Alejandro Velez, Julie A. Gosse (*contributed equally), 2016, Journal of Applied Toxicology, doi: 10.1002/jat.3300
  • “Antimicrobial Agent Triclosan is a Proton Ionophore Uncoupler of Mitochondria in Living Rat and Human Mast Cells and in Primary Human Keratinocytes,” Lisa M. Weatherly, Juyoung Shim, Hina N. Hashmi, Rachel H. Kennedy, Samuel T. Hess, and Julie A. Gosse, in press, Journal of Applied Toxicology
  • “Monomethylated Trivalent Arsenic Species Disrupt Steroid Receptor Interactions with their DNA Response Elements at Non-cytotoxic Cellular Concentrations,” Julie A. Gosse, Vivien F. Taylor, Brian P. Jackson, Joshua W. Hamilton, and Jack E. Bodwell, Journal of Applied Toxicology, 2013, doi: 10.1002/jat.2898
  • “Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study,” Dennis Liang Fei, Devin C. Koestler, Zhigang Li, Camilla Giambelli, Avencia Sanchez-Mejias, Julie A. Gosse, Carmen J. Marsit, Margaret R. Karagas, and David J. Robbins, Environmental Health, 2013, vol. 12, p. 58.
  • “A Microplate Assay to Assess Chemical Effects of RBL-2H3 Mast Cell Degranulation: Effects of Triclosan Without Use of an Organic Solvent,” Lisa M. Weatherly, Rachel H. Kennedy, Juyoung Shim, and Julie A. Gosse*, Journal of Visualized Experiments, 2013, vol. 81, e50671, doi:10.3791/50671. *corresponding author.
  • “Actin Mediates the Nanoscale Membrane Organization of the Clustered Membrane Protein Influenza Hemagglutinin,” Manasa V. Gudheti, Nikki M. Curthoys, Travis J. Gould, Dahan Kim, Mudalige S. Gunewardene, Kristin A. Gabor, Julie A. Gosse, Carol H. Kim, Joshua Zimmerberg, and Samuel T. Hess, Biophysical Journal, 2013, vol. 104, pp. 2182-2192.
  • “Visualizing the molecular timing of a physiological decision at the nanoscale,” Samuel T. Hess* and Julie A. Gosse*, Biophysical Journal, 2013, vol. 105, pp. 2617-8. *co-corresponding authors.
  • Antibacterial agent triclosan suppresses RBL-2H3 mast cell function, Rachel K. Palmer, Lee M. Hutchinson, Benjamin T. Burpee, Emily J. Tupper, Jonathan H. Pelletier, Zsolt Kormendy, Alex R. Hopke, Ethan T. Malay, Brieana L. Evans, Alejandro Velez, Julie A. Gosse*, Toxicology and Applied Pharmacology, vol. 258, 2012, pp. 99-108. *corresponding author.
  • Estrogen mimetic 4-tert-octylphenol enhances IgE-mediated degranulation of RBL-2H3 mast cells, Rachel H. Kennedy, Jonathan H. Pelletier, Emily J. Tupper, Lee M. Hutchinson, and Julie A. Gosse*, Journal of Toxicology and Environmental Health, Part A, vol. 75, 2012, pp. 1451-1455. *corresponding author.
  • Inorganic Arsenite Inhibits IgE Receptor-Mediated Degranulation of Mast Cells, Lee M. Hutchinson, Benett M. Trinh, Rachel K. Palmer, Christopher A. Preziosi, Jonathan H. Pelletier, Hannah M. Nelson, Julie A. Gosse*, Journal of Applied Toxicology, vol. 31, 2011, pp. 231-241. *corresponding author.
  • Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors, Dennis Liang Fei, Hua Li, Courtney D. Kozul, Kendall E. Black, Samer Singh, Julie A. Gosse, James DiRenzo, Kathleen A. Martin, Baolin Wang, Joshua W. Hamilton, Margaret R. Karagas, and David J. Robbins, Cancer Research, vol. 70, 2010, pp. 1981-8.
  • Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung, Courtney D. Kozul, Thomas H. Hampton, Jennifer C. Davey, Julie A. Gosse, Athena P. Nomikos, Phillip L. Eisenhauer, Daniel J. Weiss, Jessica E. Thorpe, Michael A. Ihnat, Joshua W. Hamilton, Environmental Health Perspectives, vol. 117, 2009, pp. 1108-1115
  • A new approach to analysis and interpretation of toxicogenomic gene expression data and its importance in examining biological responses to low, environmentally-relevant doses of toxicants, Julie A. Gosse, Thomas H. Hampton, Jennifer C. Davey, Joshua W. Hamilton, in book entitled Toxicogenomics: A powerful tool for toxicity assessment, edited by Saura C. Sahu, John Wiley & Sons Ltd., Oct. 2008, pp. 27-57.
  • Laboratory Diet Profoundly Alters Gene Expression and Confounds Genomic Analysis in Mouse Liver and Lung, Courtney D. Kozul, Athena P. Nomikos, Thomas H. Hampton, Linda A. Warnke, Julie A. Gosse, Jennifer C. Davey, Jessica E. Thorpe, Brian P. Jackson, Michael A. Ihnat, Joshua W. Hamilton, Chemico-Biological Interactions, vol. 173, 2008, p. 129-140.
  • Nanoscale imaging of molecular positions and anisotropies, Travis J. Gould, Mudalige S. Gunewardene, Manasa V. Gudheti, Vladislav V. Verkhusha, Shu-Rong Yin, Julie A. Gosse, Samuel T. Hess, Nature Methods, vol. 5, 2008, pp. 1027-30.
  • Arsenic as an endocrine disruptor: Effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture, Jennifer C. Davey, Jack E. Bodwell, Julie A. Gosse, Joshua W. Hamilton, Toxicological Sciences, vol. 98, 2007, pp. 75-86.
  • Arsenic disruption of steriod receptor gene activation: Complex dose-response effects are shared by several steroid receptors, Jack E. Bodwell, Julie A. Gosse, Athena P. Nomikos, Joshua W. Hamilton, Chemical Research in Toxicology, vol. 19, issue 12, 2006, pp. 1619-29.
  • Transmembrane sequences are determinants of immunoreceptor signaling, Julie A. Gosse, Alice Wagenknecht-Wiesner, David Holowka, Barbara Baird, The Journal of Immunology, vol. 175, 2005, pp. 2123-31.
  • Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells, Daniel R. Larson*, Julie A. Gosse*, David A. Holowka, Barbara A. Baird, Watt W. Webb (*First two authors contributed equally to this work), The Journal of Cell Biology, vol. 171, 2005, pp. 527-36.
  • Lipid segregation and IgE receptor signaling: A decade of progress, David Holowka, Julie A. Gosse, Adam T. Hammond, Xuemei Han, Prabuddha Sengupta, Norah L. Smith, Alice Wagenknecht-Wiesner, Min Wu, Ryan M. Young, Barbara Baird, Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1746, 2005, pp. 252-9.