Joan Malcolm


B.S. Biological Engineering, University of Maine, 2007


I have a passion for working at the intersection of science and business, using data to build strategies that improve the lives of patients. I have enjoyed a 12-year career at The Jackson Laboratory where I have focused on accelerating various clinical and translational research initiatives. Eleven years of project management and five years of business management within diverse clinical and biomedical research programs have embedded me in the technologies and underlying science that are advancing the field. Along the way I found myself drawn to areas that allowed me to contribute to advancing research and decided to pursue my PhD. I have found incredible mentors in the GSBSE program and gained a deep respect for what it takes to tease out meaningful findings to advance the biomedical research field.

Research Interests

My main dissertation project focuses on the modeling of cancer therapy response in the patient-derived xenograft (PDX) model system. My work investigates the molecular evolution of a tumor as it is passaged in a xenograft model, evaluates the factors that influence the ability to determine robust treatment response in this model system, and utilizes PDX to investigate signatures of response in triple negative breast cancer.

Selected Publications

  • VanderLaan PA, Rangachari D, Mockus SM, Spotlow V, Reddi H, Malcolm J, Huberman M, Joseph L, Kobayashi S, Costa D. Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes. Lung Cancer. 2017;106:17‐21.
  • Middlebrook A, Snowden E, Porter W, Hahn F, Ferguson M, Soper B, Keck J, Malcolm J, Fillmore S, Ghanekar S, Blaesius R. Comprehensive evaluation of human immune system reconstitution in NSGTM and NSGTM‐ SGM3 toward the development of a novel Onco‐HuTM xenograft model. Cancer Res 2017;77(13 Suppl).
  • Ananda G, Mockus S, Lundquist M, Spotlow V, Simons A, Mitchell T, Stafford G, Philip V, Stearns T, Srivastava A, Barter M, Rowe L, Malcolm J, Bult C, Karuturi R, Rasmussen K, Hinerfeld D. 2015. Development and validation of the JAX Cancer Treatment Profile™ for detection of clinically actionable mutations in solid tumors. Exp Mol Pathol. Feb;98(1):106‐12. PMID: 25562415
  • Helm S, Mitchell T, Ras A, Spotlow V, Kelly K, Mockus S, Statz C, Ananda G, Malcolm J, Tsongalis G. 2015 Evaluation of the Archer FusionPlex solid Tumor Panel in the JAX Cancer Treatment Profile. ASHG 2015.
  • Spotlow V, Mitchell T, Ras A, Helm S, Kelly K, Ananda G, Malcolm J, Tsongalis G., Optimization of a Next Generation Sequencing Panel to Reduce DNA Input Concentration, Turn‐Around‐Time and Cost. November 2015 (AMP)
  • Helm S, Spotlow V, Ras A, Kelly K, Malcolm J, Tsongalis G. Evaluation of the Archer FusionPlex Solid Tumor Panel in the JAX Cancer Treatment Profile™. November 2015 (AMP)
  • Ras A, Spotlow V, Helm S, Kelly K, Malcolm J, Tsongalis J. Evaluation of QIAcube vs EZ1 Advanced XL for purification of genomic DNA from FFPE solid tumor tissue. November 2015 (AMP)
  • Kelly, K, Spotlow V, Ras A, Helm S, Malcolm J, Tsongalis G. Digital Imaging as a Quality Control Metric for Next Generation Sequencing. October 2015 (NNECOS)

Selected Patents

  • Animal Tag Applicator (US8696684B2)
  • Method, Article, and Apparatus for Cryopreservation of Biological Samples (US2008/0269549 A1)
  • Animal Identification Cartridge (US14877969 pending)
  • Biomaterial Handling Device (US13765978 pending)

Selected Grants

  • “Maine Cancer Genomic Initiative” June 2018, Harold Alfond Foundation – Award Funding: $8,410,000
  • “Complex Workflow Management: An Engineered Solution” – Team Member, 100%, Award Funding: $900,000
  • “Expanding The Jackson Laboratory Product Development Pipeline” – August 11, 2008, Team Member, 100%, Maine Technology Institute, Maine Technology Asset Fund – Award Funding: $4,700,000
  • “Automation of in vitro Fertilization Technologies” – April 10, 2008‐March 31, 2009, Co‐PI, 25%, Maine Technology Institute Seed Grant ‐ Award Funding: $12,500

Dissertation Mentor

Joan Malcolm