Srinidi Mohan

Education

  • B.Sc University of Madras, 2000
  • M.Sc University of Madras, 2003
  • Ph.D. Mississippi State University, 2006

Research Interests

  1. Novel blood-based biomarker development for estrogen-receptor-negative cancer prognosis, disease progression monitoring and treatment outcome
  2. Delineate nitric oxide metabolic pathway for novel drug candidate

Selected Patents and Publications

Patent(s)

  • Mohan, S. (2018). Methods and Diagnostics for Cancer Detection and Treatment Monitoring [U.S. Patent number., 10,073,099].
  • Mohan. S. (2021). Methods and diagnostics for cancer detection and treatment monitoring. [U.S. patent number 11,009,507].

Selective Peer-Reviewed Publications (from 2011 – present)

*, indicates corresponding author

  • Mohan, S†#. Saunders, J, Bushsbaum, J., Van Pelt, D, , Monahan, S., Dipalazzo, J, Frankenfeld, C,L., Bertaux, B, and Miesfeldt, S*. (2025). Nw-hydroxy L-Arginine (NOHA): a promising biomarker of response to neoadjuvant therapy in the management of triple negative breast cancer. Journal of Clinial Oncology Precision Medicine. Submitted in May 2025, and under review.
  • Chase, O., Graham, E., Buczek, M., Speltz, W., Steele, M., LaBonte, C, and Mohan, S*†. (2025). Assessing NOHA as an integrative, plasma-detectable biomarker linking immune checkpoint activation and inflammatory cytokine signaling in estrogen receptor negative breast Journal of Biochemistry and Biophysics Reports. Jan 26:45:102468. doi: 10.1016/j.bbrep.2026.102468.
  • Serventi, F., Musyoka, A., Saunders, J., Mremi, A., Mmbaga, B, T., Patrick, E., Mwakyembe, T., Jones, , Lucas, F, L., Miesfeldt, S., and Mohan, S*. (2022) NOHA: a promising biomarker for
  • Mohan, S*., Patel, S., Barlow, D., Rojas, A.C. (2020). Predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors. Advances in Medical Sciences. 65:424-428. doi: 10.1016/j.advms.2020.08.004
  • Mohan, S*., Lawton, S., Palmer, C., Rojas, A.C. (2019). Competitive ELISA method for novel estrogen-negative breast cancer biomarker quantification. Journal of Immunological Methods. 474:112671. doi: 10.1016/j.jim.2019.112671
  • Mohan, S*., Patel, S., Greenstein, I., Ng, C., Frazier, K., Nguyen, G., Harding, L., Barlow, D. (2018). Metabolic relevance for N-hydroxy L-arginine reduction in estrogen-negative breast cancer cells. Amino Acids. doi:10.1007/s00726-018-2603-x.
  • Mohan, S*., Greenstein, I., Ng, C., Frazier, K., Nguyen, G., Harding, L. (2017). Assessing Nw-hydroxy-L-arginine applicability as a novel ethnic specific estrogen-negative breast cancer marker. Amino Acids Journal. 50 (3–4: 373-382. doi: 10.1007/s00726-017-2523-1.
  • Mohan, S*., Harding, L., Moua, N. (2016). Nw-hydroxy-L-arginine as a novel ethnic specific indicator of estrogen-negative breast cancer. Amino Acids. 48(11):2693-2698. DOI :10.1007/s00726-016-2301-5.
  • Mohan, S*., Harding, L. (2016). Maintenance of Cytosolic Calcium is Crucial to Extend L-Arginine Therapeutic Benefits During Continuous Dosing. Nutrition Research.36(10):1114-1120. DOI: 10.1016/j.nutres.2016.07.002
  • Mohan, S*., Benson, C. (2014). Understanding the metabolic possibilities for L-Arginine tolerance development. Austin Journal of Nutrition and Food Sciences. 2(2):6.
  • Mohan S*, Patel H, Bolinaga J, Soekamto N. (2013). AMP-activated protein kinase regulates L-arginine mediated cellular responses. Nutrition and Metabolism. 10:40
  • Mohan S*, Patel H, Bolinaga J, Soekamto N, Achu L, Teklemariam K. (2012). Dihydrobiopterin (BH2): Key Determinant in influencing arginine mediated endothelial tolerance and dysfunction. American Journal of Biochemistry and Biotechnology. 8:54-62
  • Mohan S, Fung HL. (2012). Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine. International Journal of Molecular Sciences. 13:7521-7531
  • Mohan S, Wu CC, Shin S, Fung HL. (2011). Continuous exposure to L-arginine induces oxidative stress and physiological tolerance in cultured human endothelial cells. Amino Acids. 43:1179-88
  • Shin S, Mohan S, Fung HL. (2011). Intracellular L-arginine concentration does not determine NO production in endothelial cells: Implications on the “L-arginine paradox”. Biochemical and Biophysical Research Communications. 414:660-663
  • Shin S, Fung S-M, Mohan S, Fung HL. (2011). Simultaneous bio-analysis of L-Arginine, L-Citrulline and dimethylarginases by LC-MS/MS. Journal of Chromatography B. 876:467- 474