Sambuddha Paul

Education

  • BA in Biotechnology, SRM Institute of Science and Technology
  • MA in Cellular and Molecular Biology, University of New Haven

Interests

My research interests lie in immuno-oncology and translational research, with a focus on developing innovative therapeutic strategies that harness the immune system to combat cancer. I am particularly interested in studying epigenetic modifications in cancers and exploring how they can enhance the efficacy of immunotherapy.

Biography

Growing up in India, I completed a BE in Biotechnology with a research focus on lung cancer immunotherapy. I later moved to New Haven, Connecticut to pursue an MS in Cellular and Molecular Biology, graduating with a thesis analyzing the transcriptome of Borrelia burgdorferi-infected triple-negative breast cancer cells. Expanding my horizons, I worked as a Post-graduate Associate in the Halene lab at Yale Cancer Center, where I studied transgenic and humanized mice models in MDS and AML. I am deeply passionate about translational immuno-oncology, especially the role of epigenetic modifications in enhancing immunotherapy efficacy. Through the PhD program at the University of Maine, I hope to advance my research skills that will help me facilitate the translation of innovative, less toxic, and more efficient treatments for cancer into the clinic. Outside the lab, I am a soccer enthusiast, an avid reader, and a beginner ukulele player.

Publications

  • Khatri, V. A., Paul, S., Patel, N. J., Thippani, S., Sawant, J. Y., Durkee, K. L., Murphy, C. L., Aleman, G. O., Valentino, J. A., Jathan, J., Melillo, A., & Sapi, E. (2023). Global transcriptomic analysis of breast cancer and normal mammary epithelial cells infected with Borrelia burgdorferi. European journal of microbiology & immunology, 13(3), 63–76. https://doi.org/10.1556/1886.2023.00031
  • Mukherjee, O., Paul, S., Das, S., Rakshit, S., Shanmugam, G., George, M., & Sarkar, K. (2024). Doxorubicin induced epigenetic regulation of dendritic cell maturation in association with T cell activation facilitates tumor protective immune response in non-small cell lung cancer (NSCLC). Pathology, research and practice, 253, 155004. https://doi.org/10.1016/j.prp.2023.155004
  • Shanmugam, G., Das, S., Paul, S., Rakshit, S., & Sarkar, K. (2022). Clinical relevance and therapeutic aspects of professional antigen-presenting cells in lung cancer. Medical oncology (Northwood, London, England), 39(12), 237. https://doi.org/10.1007/s12032-022-01841-6
  • Amro Baassiri, Jamie Maziarz, Holly Nicole Blackburn, Hannah Maul-Newby, Jennifer VanOudenhove, Xuan Zhang, Martin Matthews, Sambuddha Paul, Wei Liu, Esen Sefik, Nathan Salomonis, H. Leighton Grimes, Richard Flavell, Stephanie Halene; MISTRG6kitW41: Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse Model. Blood 2024; 144 (Supplement 1): 1815. doi: https://doi.org/10.1182/blood-2024-211908