Joshua Hamilton

Education

• BS in Biomedical Engineering, Minor in Nanotechnology, and Highest Honors from Honors College, University of Maine
• MS in Biomedical Engineering, University of Maine

Interests

Bioinformatics/Computational Biology, Biomedical Engineering, Cancer, Immunology/Inflammation/Hematology

Brief Biography

Josh’s undergraduate research experiences revolved heavily around using cellulose nanofibers (CNF) in biomedical applications (2017-2021). His honors thesis, with Dr. Karissa Tilbury and Dr. Michael Mason, involved the force induced orientation of CNF films and validation of orientation using polarized light microscopy as CNF is a naturally birefringent material. He continued this work later on using wavelet transforms of the birefringence images to validate our older method of quantifying the orientation. Josh’s master’s research with Dr. Andre Khalil, Dr. Peter Brooks, and Dr. Karissa Tilbury involves the development of a new quantitative metric for tracking changes in collagen fiber anisotropy in the tumor microenvironment using second harmonic generation (SHG) microscopy (2021-2022). He developed the wavelet transform modulus maxima anisotropy method and applied it to 40 pancreatic cancer H&E stained slides from the Maine Medical Center Research Institute (MMCRI). His PhD research will involve a larger study with 67 breast cancer slides. A fun fact about him is that he is rank #1 in Maine for the esport super smash brothers melee and well known nationally.

Publications

• Hamilton J, Breggia A, Fitzgerald TL, Jones MA, Brooks PC, Tilbury K and Khalil A (2022) Multiscale anisotropy analysis of second-harmonic generation collagen imaging of human pancreatic cancer. Front. Oncol. 12:991850. doi: 10.3389/fonc.2022.991850