Joseph Nadeau

Education

  • BA: University of Maine, Orono, ME
  • MA: University of Maine, Orono, ME
  • PhD: Boston University, Boston, MA
  • Postdoctoral Training: Max Planck Institute for Immunogenetics, Tubingen, Germany and Jackson Laboratory, Bar Harbor

Brief Biography

Unlocking the mysteries of inheritance in human health and disease and in their mouse models.

Joseph (Joe) Nadeau, PhD, is internationally recognized for his expertise in genetics and epigenetics, and for his contributions to gene mapping and studies of mouse models in human disease. His work is contributing to the way we understand inheritance of disease susceptibility. His current work explores epigenetic inheritance, modifier genes, and phenotypic noise in testicular cancer and metabolic disease.

Selected Publications

Top Five Papers

Nadeau JH, Taylor BA. Lengths of chromosomal segments conserved since divergence of man and mouse. Proc Natl Acad Sci USA 1985 Feb;81(3)814-8. PubMed PMID: 6583681; PubMed Central PMCID: PMC344928.

Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 2005 May 19;435(7040):360-4.

Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O’Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH. Genetic dissection of complex traits with chromosome substitution strains of mice. Science. 2004 Apr 16;304(5669):445-8. PubMed PMID: 15031436.

Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O’Brien W, Courtland HW, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES, Nadeau JH. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci USA. 2008 Dec 16;105(50):19910-4. PubMed PMID: 19066216; PubMed Central PMCID: PMC2604967.

Nadeau JH. (2017) Do gametes woo? Evidence for non-random their union at fertilization. Genetics 207:369-387

 

Complete List of Published Work in My NCBI