Ben Harrison

Education

PhD, University of Edinburgh, 2007

Research Interests

  • Animal Model
  • COM Faculty Research
  • COM Neuroscience and Pain
  • Gene Expression
  • Neuroscience
  • Pain
  • Sensory Neuron
  • Transcriptional Regulation
  • Transgenic Mice

Brief biography

Ben Harrison, Ph.D., completed his bachelor’s degree in molecular genetics at the University of Wales in the United Kingdom where, in conjunction with GlaxoSmithKline, he completed his undergraduate research dissertation on transcriptomics. He then went on to receive his Ph.D. from the University of Edinburgh in Scotland. In Scotland, Dr. Harrison worked under Dr. Ted Hupp and collaborated with Dr. Phillip Gordon-Weeks at the department of developmental neurobiology at King’s College London studying protein-protein interactions in signal transduction. Having decided to focus his research on mechanisms of neuroplasticity, Dr. Harrison moved to the United States for postdoctoral training at the Kentucky Spinal Cord Injury Research Center under Dr. Jeff Petruska and with Dr. Eric Rouchka at the Kentucky Bioinformatics INBRE core. Dr. Harrison’s current work focuses on understanding neuron-intrinsic signaling mechanisms during anatomical restructuring of peripheral afferent neurons.

Selected Publications

  • Harrison, Benjamin J; Venkat, Gayathri; Lamb, James L; Hutson, Tom H; Drury, Cassa; Rau, Kristofer K; Bunge, Mary Barlett; Mendell, Lorne M; Gage, Fred H; Johnson, Richard D; The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity Journal of Neuroscience 36 15 4259-4275 2016 Society for Neuroscience
  • Rau, Kristofer K; Hill, Caitlin E; Harrison, Benjamin J; Venkat, Gayathri; Koenig, Heidi M; Cook, Sarah B; Rabchevsky, Alexander G; Taylor, Bradley K; Hai, Tsonwin; Petruska, Jeffrey C; Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress-and nerve injury-associated genes in sensory neurons Experimental neurology 283 413-427 2016 Academic Press
  • Rouchka, Eric C; Chariker, Julia H; Harrison, Benjamin J; Park, Juw Won; Cao, Xueyuan; Pounds, Stanley; Raimondi, Susana; Downing, James; Ribeiro, Raul; Rubnitz, Jeffery; Proceedings of the 15th Annual UT-KBRIN Bioinformatics Summit 2016 BMC Bioinformatics 17 10 297 2016 BioMed Central
  • Saka, Ernur; Harrison, Benjamin J; West, Kirk; Petruska, Jeffrey C; Rouchka, Eric C; Region-based custom chip description formats for reanalysis of publicly available affymetrix® genechip® data sets Computational Advances in Bio and Medical Sciences (ICCABS), 2016 IEEE 6th International Conference on 1-Jan 2016 IEEE
  • Hougland, M Tyler; Harrison, Benjamin J; Magnuson, David SK; Rouchka, Eric C; Petruska, Jeffrey C; The transcriptional response of neurotrophins and their tyrosine kinase receptors in lumbar sensorimotor circuits to spinal cord contusion is affected by injury severity and survival time Plasticity of primary afferent neurons and sensory processing after spinal cord injury 197 2015 Frontiers Media SA
  • Rouchka, Eric C; Chariker, Julia H; Harrison, Benjamin J; Proceedings of the Fourteenth Annual UT-KBRIN Bioinformatics Summit 2015 BMC Bioinformatics 16 Suppl 15 I1 2015 BioMed Central Ltd
  • Harrison, Benjamin J; Venkat, Gayathri; Hutson, Thomas; Rau, Kristofer K; Bunge, Mary Bartlett; Mendell, Lorne M; Gage, Fred H; Johnson, Richard D; Hill, Caitlin; Rouchka, Eric C; Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model Genomics Data 6 249-252 2015 Elsevier
  • Harrison, Benjamin J; Flight, Robert M; Gomes, Cynthia; Venkat, Gayathri; Ellis, Steven R; Sankar, Uma; Twiss, Jeffery L; Rouchka, Eric C; Petruska, Jeffrey C; IB4‐binding sensory neurons in the adult rat express a novel 3′ UTR‐extended isoform of CaMK4 that is associated with its localization to axons Journal of Comparative Neurology 522 2 308-336 2014 Wiley Online Library
  • Flight, Robert M; Harrison, Benjamin J; Mohammad, Fahim; Bunge, Mary B; Moon, Lawrence DF; Petruska, Jeffrey C; Rouchka, Eric C; categoryCompare, an analytical tool based on feature annotations Frontiers in genetics 5 98 2014 Frontiers
  • Rau, K; Spears, C; Harrison, B; Venkat, G; Johnson, R; Cooper, B; Petruska, J; (350) Molecular and electrophysiological characterization of sensory neurons after muscle incision Journal of Pain, The 15 4 S63-S63 2014 Elsevier
  • Ward, Patricia J; Herrity, April N; Smith, Rebecca R; Willhite, Andrea; Harrison, Benjamin J; Petruska, Jeffrey C; Harkema, Susan J; Hubscher, Charles H; Novel Multi-System Functional Gains via Task Specific Training in Spinal Cord Injured Male Rats Journal of neurotrauma 31 9 819-833 2014 Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA
  • Lemmon, Vance P; Ferguson, Adam R; Popovich, Phillip G; Xu, Xiao-Ming; Snow, Diane M; Igarashi, Michihiro; Beattie, Christine E; Bixby, John L; Consortium, MIASCI; Abeyruwan, Saminda W; Minimum Information About a Spinal Cord Injury Experiment (MIASCI)–a proposed reporting standard for spinal cord injury experiments Journal of neurotrauma ja 2014
  • Harrison, Benjamin J; Flight, Robert M; Eteleeb, Abdallah M; Rouchka, Eric C; Petruska, Jeffrey C; UTR extension and alternate polyadenylation in neuroplasticity: an emerging paradigm? BMC Bioinformatics 15 10 P11 2014 BioMed Central
  • Eteleeb, Abdallah M; Flight, Robert M; Harrison, Benjamin J; Petruska, Jeffrey C; Rouchka, Eric C; An Island-Based Approach for Differential Expression Analysis Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics 419 2013 ACM
  • Rau, K; Harrison, B; Venkat, G; Hill, C; Petruska, J; Molecular and electrophysiological changes induced by skin incision: implications for the development of chronic pain Journal of Pain, The 14 4 S53-S53 2013 Elsevier
  • Mohammad, Fahim; Flight, Robert M; Harrison, Benjamin J; Petruska, Jeffrey C; Rouchka, Eric C; AbsIDconvert: An absolute approach for converting genetic identifiers at different granularities BMC bioinformatics 13 1 229 2012 BioMed Central Ltd
  • Harrison, Benjamin J; Flight, Robert M; Eteleeb, Abdallah; Rouchka, Eric C; Petruska, Jeffrey C; RNASeq profiling of UTR expression during neuronal plasticity BMC Bioinformatics 13 Suppl 12 A4 2012 BioMed Central
  • Mohammad, Fahim; Flight, Robert M; Harrison, Benjamin J; Petruska, Jeffrey C; Rouchka, Eric C; Interval Trees for Detection of Overlapping Genetic Entities Bioinformatics and Bioengineering (BIBE), 2011 IEEE 11th International Conference on 278-281 2011 IEEE
  • Mohammad, Fahim; Flight, Robert M; Harrison, Benjamin J; Petruska, Jeffrey C; Rouchka, Eric C; 2011 11th IEEE International Conference on Bioinformatics and Bioengineering BIBE 2011
  • Mohammad, Fahim; Flight, Robert M; Harrison, Benjamin J; Petruska, Jeffrey C; Rouchka, Eric C; A Heuristic Algorithm for Detecting Intercellular Interactions Bioinformatics and Bioengineering (BIBE), 2011 IEEE 11th International Conference on 8-Jan 2011 IEEE
  • Flight, Robert M; Petruska, Jeffrey C; Harrison, Benjamin J; Rouchka, Eric C; categoryCompare: high-throughput data meta-analysis using gene annotations BMC Bioinformatics 12 7 A16 2011 BioMed Central
  • Hill, Caitlin E; Harrison, Benjamin J; Rau, Kris K; Hougland, M Tyler; Bunge, Mary Bartlett; Mendell, Lorne M; Petruska, Jeffrey C; Skin incision induces expression of axonal regeneration-related genes in adult rat spinal sensory neurons The Journal of Pain 11 11 1066-1073 2010 Elsevier
  • Stevens, Craig; Lin, Yao; Harrison, Ben; Burch, Lindsay; Ridgway, Rachel A; Sansom, Owen; Hupp, Ted; Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling Journal of biological chemistry 284 1 334-344 2009 ASBMB
  • Lin, Yao; Stevens, Craig; Harrison, Ben; Pathuri, Suresh; Amin, Eliana; Hupp, Ted R; The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization Molecular and cellular biochemistry 328 2-Jan 101-107 2009 Springer
  • Harrison, Ben; Kraus, Michaela; Burch, Lindsay; Stevens, Craig; Craig, Ashley; Gordon-Weeks, Phillip; Hupp, Ted R; DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing Journal of biological chemistry 283 15 9999-10014 2008 American Society for Biochemistry and Molecular Biology
  • Lin, Yao; Stevens, Craig; Hrstka, Roman; Harrison, Ben; Fourtouna, Argyro; Pathuri, Suresh; Vojtesek, Borek; Hupp, Ted; An alternative transcript from the death‐associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing FEBS journal 275 10 2574-2584 2008 Wiley Online Library
  • Craig, Ashley L; Chrystal, Jennifer A; Fraser, Jennifer A; Sphyris, Nathalie; Lin, Yao; Harrison, Ben J; Scott, Mary T; Dornreiter, Irena; Hupp, Ted R; The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members Molecular and cellular biology 27 9 3542-3555 2007 Am Soc Microbiol
  • Rau, K; Spears, C; Harrison, B; Venkat, G; Johnson, R; Cooper, B; Petruska, J; root ganglion reduces pain caused by local inflammatory irritation
  • The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity