Aric Rogers

Education

• Ph.D., University of Massachusetts, Molecular and Cellular Biology, 2005

Brief Biography

How is gene expression remodeled under conditions that extend lifespan?

Using the model organism C. elegans, the Rogers Lab focuses at points of regulation that occur after transcription. Genetic variations and environmental conditions that result in lifespan extension are also associated with delaying the onset of age-related diseases including diabetes, cancer, and neurodegeneration. The goal of the Rogers Lab is to understand how life-extending interventions work across different species and apply what is learned to extend human health and longevity.

Selected Publications

• Harper S Kim, Danitra J Parker, Madison M Hardiman, Erin Munkácsy, Nisi Jiang, Aric N Rogers, Yidong Bai, Colin Brent, James A Mobley, Steven N Austad, Andrew M Pickering. Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling. Nat Commun . 2023 Aug 18;14(1):5021. doi: 10.1038/s41467-023-40618-x. PMID: 37596266; PMCID: PMC10439225.
• Kumar AV, Kang T, Thakurta TG, Ng C, Rogers AN, Larsen MR, Lapierre LR. Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP. Sci Adv. 2022 Apr;8(13):eabj1604. doi: 10.1126/sciadv.abj1604. Epub 2022 Apr 1. PMID: 35363528.
• Heissenberger C, Rollins JA, Krammer TL, Nagelreiter F, Stocker I, Wacheul L, Shpylovyi A, Tav K, Snow S, Grillari J, Rogers AN, Lafontaine DLJ, Schosserer M. The ribosomal RNA m⁵C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. Elife. 2020 Dec 8;9:e56205. doi: 10.7554/eLife.56205. PMID: 33289480; PMCID: PMC7746234.
• Lan J, Rollins JA, Zang X, Wu D, Zou L, Wang Z, Ye C, Wu Z, Kapahi P, Rogers AN, Chen D. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 2019 Jul 23;28(4):1050-1062.e6. doi: 10.1016/j.celrep.2019.06.078. PMID: 31340143; PMCID: PMC6684276.

More publications here.