Aric Rogers

Education

  • PhD, 2006, Molecular and Cellular Biology, University of Massachusetts

Overview

DR ARIC ROGERS is Assistant Professor of Regenerative Biology and Medicine at MDI Biological Laboratory. He was born and grew up near Seattle, Washington. He received his PhD in Molecular and Cellular Biology from the University of Massachusetts Amherst. In 2005, he began postdoctoral research at the Buck Institute for Research on Aging under the guidance of Dr. Pankaj Kapahi. His studies focused on adaptive mechanisms responsible for lifespan extension when mRNA translation is genetically attenuated. He discovered that restricting a nutrient-responsive translation factor, while globally reducing total protein synthesis, enhanced relative translation rates of pro-longevity genes. Furthermore, he showed that some of these longevity factors were required for increased lifespan when translation is restricted.

In 2013, he started his own lab at the MDI Biological Laboratory, using the small roundworm C. elegans to study how gene expression is remodeled under conditions that extend lifespan, particularly at points of regulation that occur after transcription. Genetic variations and environmental conditions that result in lifespan extension are also associated with delaying the onset of age-related diseases including diabetes, cancer, and neurodegeneration. The goal of his lab is to understand how life-extending interventions work across different species and apply what is learned to extend human health and longevity. Current research projects are focused on understanding how environmental changes, such as exposure to physical stress or nutrient restriction, remodel post-transcriptional gene expression as part of an evolutionarily conserved adaptive response to increase survival. This is key to understanding how interventions like dietary restriction or direct attenuation of translation factor gene expression are able to increase lifespan and organismal homeostasis. In 2019, his lab received an R01 from the NIA to study the role of mRNA translation in adaptation to dietary restriction.

Selected Publications

  • Lan J, Rollins JA, Zang X, Wu D, Zou L, Wang Z, Ye C, Wu Z, Kapahi P*, Rogers AN*, Chen D* (2019). Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 2019 Jul 23;28(4):1050-1062. Free full text available on PubMed. * – co-corresponding authors
  • Rollins JA, Shaffer D, Snow SS, Kapahi P, Rogers AN* (2019). Dietary restriction induces posttranscriptional regulation of longevity genes. Life Sci Alliance. 2019 Jun 28;2(4). Available on PubMed * – indicates corresponding author
  • Adamla F, Rollins J, Newsom M, Snow S, Schosserer M, Heissenberger C, Horrocks J, Rogers AN*, Ignatova Z* (2019). A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging. Cellular Physiology and Biochemistry Free full text available on PubMed * – co-corresponding authors
  • Rollins, J., Amber Howard, Sarah Dobbins, Elsie Washburn, and Aric N. Rogers (2017). Assessing healthspan in C. elegans: Lessons from short-lived mutants. The Journals of Gerontology: Series A, 72(4), 473–480. PMID: 28158466
  • Howard, A., Jarod Rollins, Santina Snow, Sarah Castor, and Aric N. Rogers (2016). Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans. Aging Cell. PMID: 27538368.
  • Rollins, J and Aric N. Rogers (2016). Chapter 13: Translational control of longevity in “Ageing: Lessons from C. elegans,” eds. A Olson and MS Gill, Springer Publishing. doi:10.1007/978-3-319-44703-2_13
  • Coffman, J. A., Sandra Rieger, Aric N. Rogers, Dustin L. Updike, and Viravuth P. Yin (2016). Comparative Biology of Tissue Repair, Regeneration, and Aging. Nature Publishing Journals, Regenerative Medicine. doi:10.1038/npjregenmed.2016.3
  • Wilson-Edell, K. A., M. A. Yevtushenko, D. E. Rothschild, Aric N. Rogers, and Christopher C. Benz (2014). mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms. Breast Cancer Res Treat, 144(2), 287-298. PMCID: PMC4318538
  • Howard, A. and Aric N. Rogers (2014). Role of Translation Initiation Factor 4G in Lifespan Regulation and Age-related Health. Ageing Research Reviews, 13C, 115-124. PMCID: 3966135
  • Rogers, A. N., Di Chen, Gawain McColl, Gregg Czerwieniec, Krysta Felkey, Bradford W. Gibson, Alan Hubbard, Simon Melov, Gordon J. Lithgow, and Pankaj Kapahi (2011). Lifespan extension via eIF4G inhibition is mediated by post-transcriptional remodeling of stress response gene expression in C. elegans. Cell Metabolism, 14, 55-66. PMCID:3220185
  • McColl, G., Aric N. Rogers, Sylvestre Alavez, Alan E. Hubbard, Simon Melov, Christopher D. Link, A. I. Bush, Pankaj Kapahi, and Gordon J. Lithgow (2010). Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metabolism, 12(3), 260-272. PMCID: 2945254
  • Kapahi P, Di Chen, Aric N. Rogers, Subash D. Katewa, Patrick W. Li, Emma L. Thomas, and L. Kockel (2010). With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metabolism. 2010 Jun 9;11(6):453-65. PMCID: PMC2885591
  • Zid B. M., Aric N. Rogers, Subhash D. Katewa, T. Au Lu, Seymour Benzer, and Pankaj Kapahi. (2009). 4E-BP modulates lifespan and mitochondrial translation upon dietary restriction in Drosophila. Cell, 139(1), 149-160. PMCID: 2759400
  • Pan K. Z., Julia E. Palter, Aric N. Rogers, Di Chen, Anders Olsen, Gordon J. Lithgow, and Pankaj Kapahi (2007). Life Extension by Inhibition of mRNA Translation. Aging Cell, 6, 111-119. PMCID: PMC2745345

Grants

  • 2011 to 2016 — $923,580.00 — K99/R00 from NIA – NIH
  • 2013 to 2018 — $400,000.00 — New Scholar Award from The Ellison Medical Foundation
  • 2018 to 2020 — $455,000.00 —R21 from the NIA-NIH
  • 2019 to 2024 — $1,867,500.00 — R01 from NIA/NIGMS