Marie J. Hayes


Ph.D. in Experimental Psychology, Postdoctoral in Neuropharmacology

Research Interests

Our laboratory uses neurophysiological behavioral and actigraphic recordings for sleep studies to examine CNS functioning in high risk human neonate. Based on animal model findings demonstrating disruption of cholinergic neurotransmission with prenatal exposure to opioid compounds such as methadone, we have been testing early electrophysiological correlates of prefrontal development of attention and recognition memory in neonates in withdrawal from prenatal opioid exposure.  Our previous work in normative and high risk samples has investigated the hypothesis that the pattern and rhythmicity of sleep-dependent spontaneous movements functions as a primitive arousal system that is protective for Sudden Infant Death Syndrome. High risk for SIDS samples such as premature infants with apnea and dysmature infants, e.g. prenatally exposed to opiates, alcohol, tobacco, are found to have reductions in the robustness of this system.

Another line of work examines prospectively the development of anxiety disorders in children following trauma and under laboratory conditions of mild stress. Future studies will incorporate neuroendocrine/neurobiological correlates of stress reactivity such as NPY, CRH and cortisol during the development of the stress disorder.

Selected Publications

In Press

  • Hayes, M.J., McCoy, S.K., DiPietro, J.A., Fukumizu, M. & Joseph D. Wellman. (in press). Temperament and sleep-wake behaviors from infancy to toddlerhood. Infant and Child Development.

Additional Publications

  • Matano, B.A., Hayes, M.J., Brown, M., Tisher, P., Krishnan R. and Paul, J.A. (2009). Main’s high risk infants and maternal helath and wellbeing, Maine Policy Review, 18, 60-65.
  • Troese, M., Sallinen, B.J., Gilles, A.A., Troese, M., Fukumizu, M., Brown, E. & Hayes, M.J. (2008). Sleep fragmentation and evidence for sleep debt in alcohol-exposed infants. Early Human Development, 80, 577-585.
  • Giganti, F., Hayes, M.J., Cioni, G. & Salzarulo, P. (2007) Yawning frequency and distribution in preterm and nearterm infants assessed through 24 hour recordings. Infant Behavior & Development, 30, 641-647.
  • Hayes, M.J., Fukumizu, M., Troese, M., Sallinen, B.J. & Gilles, A.A. (2007). Social experiences in infancy and early childhood co-sleeping. Infant & Child Development, 16, 403-416.
  • Hayes, M. J., Akilesh, M. R., Gilles, A. A., Fukumizu, M., Sallinen, B.J., & Troese, M. (2007). Apneic preterms and methylxanthines: Arousal deficits, sleep fragmentation and suppressed spontaneous movement. Journal of Perinatology, 27, 782–789.
  • Fukumizu, M., Kaga, M., Kohyama, J. & Hayes, M.J. (2005). Sleep-related night-time crying (“yonakiâ€) in Japan: A community study, Pediatrics. 115, 217-224
  • Symanski, M.E., Hayes, M.J., & Akilesh, M.K. (2002). Patterns of premature newborns’ sleep-wake states before and after nursing interventions on the night shift. JOGNN, 31, 305-313.
  • Hayes, M. J., Brown, E., Hofmaster, P., Davare, A., Parker, K. G., & Raczek, J. A. (2002). Prenatal alcohol intake in a rural, Caucasian clinic. Family Medicine, 34(2), 120-125.
  • Giganti, F., Hayes, M. J., Akilesh, M. R., & Salzarulo, P. (2002). Yawning and behavioral status in preterm infants. Developmental Psychobiology, 41, 289-296.
  • Hayes, M. J., Parker, K. G., Sallinen, B., & Davare, A. (2001). Bedsharing, temperament and sleep disturbance in early childhood. Sleep, 24, 657-662
  • Hayes, M. J., Roberts, S., & Davare, A. A. (2000). Transactional conflict between psychobiology and culture in the etiology of postpartum depression. Medical Hypothesis, 54, 7-17.
  • Hayes, M. J., & Mitchell, D. (1998). Spontaneous movements during sleep: Temporal organization and changes with age. Developmental Psychobiology, 32, 13-21.