David Mokler

Education

B.S. Psychology,Michigan State University, 1974
Ph.D. Pharmacology/Toxicology and Neuroscience, 1984

Biosketch

David Mokler, Ph.D. graduated with a B.S. in Psychology from Michigan State University in 1974 and a Ph.D.s in Pharmacology/Toxicology and Neuroscience from Michigan State University in 1984. He received a post-doctoral fellowship from the National Institute on Drug Abuse for research at the Medical College of Virginia. He joined the faculty at the University of New England College of Osteopathic Medicine in 1986. He is currently Professor of Pharmacology and Chair in the Department of Biomedical Sciences. His research has focused on the serotonergic systems of the mammalian brain. He has published in the areas of the behavioral effects of hallucinogenic drugs, the neurotoxic effects of MDMA, the serotonergic systems of the brains of children who have died of sudden infant death syndrome (SIDS), the effects of prenatal protein malnutrition on the neurochemistry of the adult rat brain, and the development of the prefrontal cortex of the rat.

Research Interests

David Mokler, Ph.D. is Professor of Pharmacology in the Department of Biomedical Sciences at the College of Osteopathic Medicine at the University of New England.  His research interests are in the area of the physiology and pharmacology of the forebrain.  His work has been funded by the National Institute of Drug Abuse, the National Institute of Child Health and Human Development and the National Institute of Mental Health.  His current work has focused on the development of the the prefrontal cortex of the rat with a focus on the effects of prenatal protein malnutrition.  Recent research has also focused on the organization of the serotonergic systems of the rat brain.  He has also worked on the effects of exposure to drugs of abuse on the brain.  He has lectured widely on topics in pharmacology and neuroscience and teaches pharmacology at the University of New England.

Selected Publications

  • Bove, G., Chapelle, S.L., Hanlon, K.E., Diamond, M. and Mokler, D.J. Attenuation of postoperative adhesions using a modeled manual therapy. PLOS ONE, in press, 2017. PMID: 28574997
  • Mokler, D.J., Miller, C.E., McGaughy, J.A. Evidence for a role of corticopetal, noradrenergic systems in the development of executive function. Neurobiol Learn Mem., 143: 94-100, 2017. PMID: 28219751.
  • Bove, G.M., Chapelle, S.L., Boyle, E., Mokler, D.J., Hartvigsen, J. A novel method for evaluating postoperative adhesions in rats. Journal of Investigative Surgery, 30: 88-94, 2017. PMID: 27690703
  • Mokler, D.J., Rigdon, A., and Schildroth, S. The Herbal Cabinet. Biomedical Sciences Faculty Projects, 2016. Book 1. http://dune.une.edu/biomed_facproj/1
  • Peter, C., Fischer, L.K., Kundakovic, M., Garg, P., Jakovcevski, M., Dincer, A., Amaral, A., Ratner, C., Galdzicka, M., Medford, G., Waber, D., Bryce, C.P., Ginns, E.I., Mokler, D., Champagne, F.A., Rosene, D.L., McGaughy, J.A., Sharp, A.J., Galler, J., Akbarian,S. DNA methylation signatures of early childhood malnutrition associated with impairments in attention and cognition. Biological Psychiatry, 80 (10): 765 – 774, 2016. PMID: 27184921
  • Fischer, L.K., Bradshaw, S.E., McGaughy, J. A., Fitzmaurice, G., Amaral, A.C., Rosene, D.L., Weissner, W., Mokler, D.J., and Galler, J.R. Prenatal Protein Level Impacts Homing Behavior in Long-Evans Rat Pups., Nutritional Neuroscience 19(5), 187-195, 2016. PMID: 25603489
  • Amaral, A.C., Jakovcevski, M., McGaughy, J.A., Calderwood, S.K., Mokler, D.J., Rushmore, R.J., Galler, J.R., Akbarian, S.A., Rosene, D.L. Prenatal protein malnutrition decreases kcnj3 and 2dg activity in rat prefrontal cortex. Neuroscience 286, 79-86, 2015. PMID: 25446346
  • McGaughy, J.A., Amaral, A.C., Rushmore, R.J, Mokler, D. J., Morgane, P. J., Rosene, D.L., and Galler, J.R. Prenatal malnutrition leads to deficits in attentional set shifting and decreases metabolic activity in prefrontal subregions that control executive function, Developmental Neuroscience 36(6), 532-41, 2014. PMID: 25342495
  • Rech, R.H., Mokler, D.J., Briggs, S.L. Effects of combined opioids on pain and mood in mammals. Pain Research and Treatment 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324919/
  • Staiti, A.M., Morgane, P.J., Galler, J.R., Grivetti, J.Y., Bass, D.C., and Mokler, D.J. A microdialysis study of the medial prefrontal cortex of adolescent and adult rats. Neuropharmacology 61(3), 544-549, 2011. PMCID3110585.
  • Rech, R.H., Briggs, S.L. and Mokler, D.J. Fentanyl and spiradoline interactions in a place-conditioning black-white shuttle-box. Pharmaceuticals 4: 101-116, 2011. Download file (PDF)
  • Staiti, A.M., Morgane, P.J., Galler, J.R., Grivetti, J.Y., Bass, D.C., and Mokler, D.J. A microdialysis study of the medial prefrontal cortex of adolescent and adult rats. Neuropharmacology 61(3), 544-549, 2011. Download file (PDF)
  • Duncan, J.R., Paterson, D.S., Hoffman, J.M., Mokler, D.J., Borestein, N.S., Belliveau, R.A., Krous, H.F., Haas, E.A., Stanley, C., Nattie, E.E., Trachtenberg, F.L. and Kinney, H.C. Brainstem serotonergic deficiency in the sudden infant death syndrome. Journal of the American Medical Association, 303 (5): 430-437, 2010. Download file (PDF)
  • Mokler, D.J., Dugal, J.R., Hoffman, J.M. and Morgane, P.J. Functional interrelations between nucleus raphé dorsalis and nucleus raphé medianus: A dual probe microdialysis study of glutamate-stimulated serotonin release. Brain Research Bulletin, 78 (4-5): 132-138, 2009. Download file (PDF)
  • Mokler, D.J., Torres, O., Galler, J.R. and Morgane, P.J. Stress-induced changes in dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats. Brain Res. 1148, 226-233, 2007. Download file (PDF)
  • Morgane, P.J. and Mokler, D.J. (eds.) Limbic Brain: Structure and Function. Special Issue, Neuroscience and Biobehavioral Reviews, 30(2), 2006.
  • Morgane, P.J. and Mokler, D.J. The limbic brain: Continuing Resolution. Neuroscience and Biobehavioral Reviews, 30(2), 119-125, 2006. Download file (PDF)
  • Morgane, P.J., Galler, J.R., Mokler, D.J. A review of systems and networks of the limbic forebrain/limbic midbrain. Prog. Neurobiol. 75(2): 143-160, 2005. Download file (PDF)
  • Turner,T.J., Mokler, D.J., Luebke, J.I. Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: In vitro slice and synaptosome studies. Neuroscience 129 (3): 709-718, 2004. Download file (PDF)

Grants

  • 2007 to 2012 — $1,200,000.00 — Malnutrition and Mental Health from National Institute of Mental Health