Christopher Grindrod

Education

PhD, McGill University (2004)

Research Interests

In the Neurolinguistics and Aphasia Research Lab, we study the neural basis of semantic processing in an effort to provide insight into the functional architecture of the language processing system. We use both psycholinguistic methods to study language processing in individuals with acquired brain damage and neuroimaging techniques, namely functional magnetic resonance imaging (fMRI), to study language processing in healthy adults. Among the patient populations we work with are individuals with aphasia, patients with right hemisphere brain damage and individuals with Parkinson’s disease. Our ultimate goal is to understand the biological basis of language, as well as differences in how the left and right hemispheres process language. Our research has both theoretical importance for models of language comprehension and also clinical significance for intervention strategies and rehabilitation techniques targeted at individuals with acquired brain injuries.

Hemispheric Asymmetries in Language Comprehension

Our primary research is focused on understanding differences in how the left and right cerebral hemispheres derive meaning from the linguistic input. Although language is in large part accomplished by the left hemisphere, there is increasing evidence that the right hemisphere also contributes to certain aspects of linguistic processing. This is particularly true in the area of semantic processing. Much of our work has been concerned with the role of the cerebral hemispheres in using sentence context information, especially as it relates to understanding indeterminacy in language, as seen when processing semantic ambiguity (e.g., bark: the sound of a dog or the outer layer of a tree) and syntactic ambiguity (e.g., I saw the man with the binoculars). Findings from our research suggest that left hemisphere brain structures are important for performing meaning selection whereas right hemisphere structures are critical for computing alternative, sometimes less frequent interpretations.

Aging and Language Comprehension

A second line of research is focused on how age-related changes in the brain impact language comprehension. To date, few age-related language declines, other than word finding difficulty, have been documented. In fact, vocabulary size and word knowledge can increase into adulthood. Despite the apparent persistence of some language functions with aging, recent research indicates that higher-level language abilities, such as integrating individual word meanings into the overall sentence meaning, are vulnerable to age-related decline. To address this issue, we are using a combination of brain imaging techniques to investigate which language-related brain areas are most affected by aging and whether there is a slowing in the way word- and sentence-level information are processed as we age. The ultimate goal of this research is to develop language-based interventions to potentially ward off early cognitive decline or dementia.

Selected Publications

  • Grindrod, C.M., Garnett, E.O., Malyutina, S., & den Ouden, D.B. (2014). Effects of representational distance between meanings on the neural correlates of semantic ambiguity. Brain and Language, 139, 23-35.
  • Grindrod, C.M. (2012). Effects of left and right hemisphere damage on sensitivity to global context during lexical ambiguity resolution. Aphasiology, 26, 933-952.
  • Loucks, T.M., Ofori, E., Grindrod, C.M., De Nil, L.F., & Sosnoff, J.J. (2010). Auditory motor integration in oral and manual effectors. Journal of Motor Behavior, 42, 233-239.
  • Monetta, L., Grindrod, C.M., & Pell, M.D. (2009). Irony comprehension and theory of mind deficits in patients with Parkinson’s disease. Cortex, 45, 972-981.
  • Bilenko, N.Y., Grindrod, C.M., Myers, E.B., & Blumstein, S.E. (2009). Neural correlates of semantic competition during processing of ambiguous words. Journal of Cognitive Neuroscience, 21, 960-975.
  • Britton, B., Blumstein, S.E., Myers, E.B., & Grindrod, C.M. (2009). The role of spectral and durational properties on hemispheric asymmetries in vowel perception. Neuropsychologia, 47, 1096-1106.
  • Grindrod, C.M., Bilenko, N.Y., Myers, E.B., & Blumstein, S.E. (2008). The role of the left inferior frontal gyrus in implicit semantic competition and selection: An event-related fMRI study. Brain Research, 1229, 167-178.
  • Monetta, L., Grindrod, C.M., & Pell, M.D. (2008). Effects of working memory capacity on inference generation during story comprehension in adults with Parkinson’s disease. Journal of Neurolinguistics, 21, 400-417.
  • Grindrod, C.M. & Baum, S.R. (2005). Hemispheric contributions to lexical ambiguity resolution in a discourse context: Evidence from individuals with unilateral left and right hemisphere lesions. Brain and Cognition, 57, 70-83.
  • Grindrod, C.M. & Baum, S.R. (2003). Sensitivity to local sentence context information in lexical ambiguity resolution: Evidence from left- and right-hemisphere-damaged individuals. Brain and Language, 85, 503-523.
  • Grindrod, C.M. & Baum, S.R. (2002). Sentence context effects and the timecourse of lexical ambiguity resolution in nonfluent aphasia. Brain and Cognition, 48, 381-385.