The major challenge in biomedical and biological research for now and the foreseeable future is to understand how the information encoded by the genome determines an organism's functions. To move from the level of the DNA sequence to an understanding of the morphogenetic and physiological pathways crucial for normal development requires new approaches to acquiring and analyzing data on a genome-wide scale. The field of Functional Genomics is a highly interactive, interdisciplinary research environment that brings together biologists, computer and information scientists, mathematicians, engineers, biophysicists, and chemists to examines fundamental biological processes and improves our understanding of related to gene and protein function and interactions. Dynamic aspects of gene transcription, translation, and protein-protein interactions are analyzed. Under the guidance of two mentors, one in the biological sciences and one in the computational/ or physical sciences, students in the Functional Genomics Track program merge these fields to develop a multidisciplinary, multidimensional program of study. The degree program provides a bridge that links a set of interdependent research cores in genetics/genomics, cell/molecular biology, biophysics/bioengineering, and computational biology/bioinformatics. Examples of ongoing research projects include super-resolution imaging of viral entry into cells, mathematical modeling of muscle development, and spectroscopic analysis of non-canonical protein translocation.
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Interests:
Gene Ontology, Genome Informatics, Functional Genomics,
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Interests:
Regulation of integrin-mediated cellular communication with the extracellular matrix (ECM) with angiogenesis, tumor growth and metastasis.
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Interests:
bioinformatics, genomics, cancer, lung development and disease
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Interests:
Development, embryo, transcription, genomics, evolution
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Interests:
MEMS, nanofabrication, micromechanical components, microphotonic devices
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Interests:
Neuromuscular disease, mouse genetics, disease biology, motor neurons, skeletal muscles
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Interests:
epilepsy, genetics, complex traits, neurogenetics
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Interests:
computational biology bioinformatics genomics mRNA processing gene expression polyadenylation post-transcriptional gene processing
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Interests:
Spermatogenesis, Testis Development, Infertility Genetic Models
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Interests:
Cell and molecular biology of segmentation and muscle development in Zebrafish
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Interests:
Super-Resolution Microscopy, Instrumentation Development, Biomembrane Organization, and Influenza
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Interests:
computational biology, bioinformatics, machine learning, data mining, visualization
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Interests:
functional genomics, gene expression, nuclear organization, transposons
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Interests:
Image Analysis, Signal Processing, Computational Modeling
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Interests:
Zebrafish, zebrafish disease, disease modeling, infection
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Interests:
Complex trait genetics,
Systems genetics,
Cardiovascular disease,
Renal disease.
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Interests:
Vascular development and remodeling, cancer biology
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Interests:
Determination of the orientation and conformation of interfacial species; surface spectroscopies/microscopies; model cellular membranes; biological and chemical sensors
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Interests:
embryonic kidney progenitor cells, organogenesis, tissue engineering, acute kidney injury
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Interests:
Regeneration, Peripheral nervous system, wound reapir
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Interests:
Genome Structure and Function Within the Nucleus
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Interests:
Microfluidic instruments for biomolecular analysis, microsensors, biomedical microdevices
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Interests:
Lamin B nuclear receptor, cholesterol biosynthesis, veterinary pharmacology/pharmacy, organic/medicinal chemistry, drug stability, cholinergic pharmacology, LCMS
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Interests:
Mechanisms of TGF-beta receptor regulation in vascular development and disease. Roles of endoglin in prostate cancer and its microenvironment. Study of biomedically-relevant models using mass spectrometry for quantitative protein analysis.
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Interests:
Candida, innate immunity, host-pathogen, dendritic, functional genomics, anti-fungal, genetics, cell biology, molecular biology, microbiology
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