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MS - Moscow University. PhD, DSc - Engelhardt Institute of Molecular Biology, Russian Academy of Sceinces.
While most extracellular proteins has in their structure a special signal peptide, required for their export through endoplasmic reticulum and Golgi, a large group of secreted proteins are devoid of signal peptides, and they are exported through insufficiently studied nonclassical mechanisms.
Our laboratory studies the stress-induced nonclassical export, of FGF1 and IL1alpha, two ubiquitous pro-inflammatory and pro-angiogenic molecules. The goals of this project is to understand how multiprotein release complexes are formed, how the released proteins are transported to the cell membrane and how they exit to the extracellular compartment without using the classical mechanism of exocytosis. The understanding of these processes will facilitate the development of new clinical approaches to the regulation of angiogenesis, inflammation and tumor growth.
Additionally, our laboratory studies the interaction between FGF/FGFR, Jagged(Delta)/Notch and thrombin/PAR1 signaling, three major regulatory systems involved in practically all of the aspects of organism development and organ formation. In particular, thrombin stimulation and downregulation of Notch signaling induce FGF1 expression and release and the acquisition of the angiogenic phenotype by the cells. The aim is to understand molecular mechanisms underlying the cross-talk between FGF, Notch and thrombin signaling and to use this knowledge for the treatment of cardiovascular and oncological disorders.