Education

Ph.D. The University of Maine 2007

Biosketch

Hong Xie, M.Sc., Ph.D., a full time Assistant Research Professor of Toxicology at the Department of Applied Medical Sciences, received her Ph.D. in Biochemistry and Molecular Biology from the University of Maine, focusing on metal toxicology.   She received her Master degree in Toxicology and Occupational Disease in the area of heavy metal renal and liver toxicity from Hunan Medical School in China.  She serves as a member of graduate committee at University of Maine and a board member of Chinese & American Friendship Association of Maine.

Dr. Xie's research interests are in the areas of heavy metal-induced carcinogenesis focusing on the genomic instability and DNA repair. Chemicals can damage the DNA directly and/or indirectly. The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The integrity of the DNA damage response pathways plays a critical role in human health.  She seeks to understand the repair pathways for metal-induced DNA double strand breaks, what causes the repair to fail and how co-exposure to one metal may alter the repair of damage induced by another metal.

1. Xie, H. and Wise, Sr., J.P. A Review of the Genetic Toxicology of Nanoparticles. In press
2. Xie H, LaCerte C, Thompson WD, Wise JP Sr. Depleted uranium induces neoplastic transformation in human lung epithelial cells. Chem Res Toxicol. 2010 Feb 15;23(2):373-8.
3. LaCerte C., Xie H., Abouiessa A. and Wise Sr., J.P. Particulate Depleted Uranium Is Cytotoxic and Clastogenic to Human Lung Epithelial Cells. Mutat Res. 2010 Mar 29;697(1-2):33-7.
4. Wise, S.S., Holmes, A.L., Qin, Q., Xie, H., Katsifis, S., Thompson, W.D. and Wise, Sr., J.P. Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in Human Bronchial Cells. Chem Res Toxicol. 2010 Feb 15;23(2):365-72
5. Xie H, Holmes AL, Young J, Qin Q, Joyce K, Pelsue S, Peng C, Wise SS, Jeevarajan AS, Wallace WT, Hammond D, Wise JP Sr. Zinc Chromate Induces Chromosome Instability and DNA Double Strand Breaks in Human Lung Cells.  Toxicol Appl Pharmacol. 2009 Feb 1;234(3):293-9
6. Xie H, Wise SS, Wise JP Sr. Deficient repair of particulate hexavalent chromium-induced DNA double strand breaks leads to neoplastic transformation. Mutat Res. 2008 Jan 8;649(1-2):230-8.
7. Xie H, Holmes AL, Wise SS, Huang S, Peng C, Wise JP Sr. Neoplastic transformation of human bronchial cells by lead chromate particles. Am J Respir Cell Mol Biol. 2007 Nov;37(5):544-52.
8. Xie H, Wise S.S., Holmes A.L., Xu B, Wakeman T. P., Pelsue S.C., Singh N.P., Wise JP Sr.  Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells. Mutat. Res. 2005, 586, 160–172
9. Xie H, Holmes AL, Wise SS, Gordon N, Wise JP Sr. Lead Chromate-Induced Chromosome Damage Requires Extracellular Dissolution to Liberate Chromium Ions but Does Not Require Particle Internalization or Intracellular Dissolution . Chem. Res. Toxicol. 2004, 17, 1362-1367
10. Wise SS, Holmes AL, Xie H, Thompson WD, Wise JP Sr. Chronic exposure to particulate chromate induces spindle assembly checkpoint bypass in human lung cells. Chem Res Toxicol. 2006 Nov;19(11):1492-8.
11. Holmes AL, Wise SS, Xie H, Gordon N, Thompson WD, Wise JP Sr. Lead ions do not cause human lung cells to escape chromate-induced cytotoxicity. Toxicol Appl Pharmacol. 2005 Mar 1;203(2):167-76.