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Ph.D. The University of Maine 2007
Hong Xie, M.Sc., Ph.D., a full time Assistant Research Professor of Toxicology at the Department of Applied Medical Sciences, received her Ph.D. in Biochemistry and Molecular Biology from the University of Maine, focusing on metal toxicology. She received her Master degree in Toxicology and Occupational Disease in the area of heavy metal renal and liver toxicity from Hunan Medical School in China. She serves as a member of graduate committee at University of Maine and a board member of Chinese & American Friendship Association of Maine.
Dr. Xie's research interests are in the areas of heavy metal-induced carcinogenesis focusing on the genomic instability and DNA repair. Chemicals can damage the DNA directly and/or indirectly. The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The integrity of the DNA damage response pathways plays a critical role in human health. She seeks to understand the repair pathways for metal-induced DNA double strand breaks, what causes the repair to fail and how co-exposure to one metal may alter the repair of damage induced by another metal.