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Molecular and Cellular Biology

The Molecular and Cellular Biology Track is an integrated, multidisciplinary graduate training program emphasizing gene function, animal development, and disease. Learn more >

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The Neuroscience Track is an integrated, interdisciplinary graduate training program examining the functions of the nervous system. Learn more >

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Students in the Biomedical Engineering track receive training in the biological, physical and computational sciences through a combination of core and advanced courses, and interdisciplinary research. Learn more >

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The Toxicology Track is an innovative, multidisciplinary graduate program investigating the consequences of exposure to chemical agents on living organisms and the environment. Learn more >

Functional Genomics

The Functional Genomics Track is a highly interactive, interdisciplinary program that brings together biologists, computer and information scientists, mathematicians, engineers, biophysicists, and chemists to examine fundamental biological processes related to gene and protein function and interactions. Learn more >

 

Harold Dowse

Harold Dowse

Contact Information

Phone:
(207) 581-2536

Email/web:
dowse@maine.edu
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Address:
School of Biology and Ecology
5751 Murray Hall 
Orono, ME  04469-5751

Education

Amherst College, BA; New York University, Ph.D.

Biosketch

I am interested in the cardiac pacemaker, specifically the calcium ion channels that underlie its oscillation.  I use genetics molecular biology and electrophysiology to unravel this problem in the Drosophila model system. 

Research Interests

In the Drosophila melanogaster system, I am investigating the intracellular calcium currents underlyling cellular oscillators, most prominently that of the cardiac pacemaker.  This involves looking at not just plasma membrane calcium channels and currents, but at the release and sequestration of calcium at the level of the sarcoplasmic reticulum and at the sodium/calcium exchanger.  The related oscillator that controls the male fly's mating song has proven informative, and we also are looking at this interesting process.  I use genetic, molecular and pharmacological tools in this investigation.

Selected Publications


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Our Programs

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Our programs include 5 tracks and more than 10 research areas.
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UMaine The Jackson Laboratory Maine Medical Center Research Institute The Mount Desert Island Biological Laboratory University of Southern Maine University of New England
 
For more information about the program, please contact:
Laura Hall, GSBSE Administrative Assistant • 207-581-4654 • gsbse@maine.edu