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GSBSE

Molecular and Cellular Biology

Molecular and Cellular Biology seeks mechanistic understanding of broad aspects of development and disease, including cell signal transduction, stem cell fate determination, and tissue homeostasis at multiple levels that include intermolecular, cell-cell, tissue and organ function. Related research within the GSBSE ranges from basic developmental and disease processes in cell and animal models from zebrafish to mouse, to studies in humans, which emphasize vascular biology, stem cell biology, tissue development, homeostasis and pathology. Learn more >

Neuroscience

Neuroscience is an intrinsically broad discipline aimed at understanding large issues such as cognition, behavior, and neurological systems at levels that include the underlying anatomical and cellular circuits, and even the molecular events that control cell excitability, synaptic function, and development. Neuroscience research within the GSBSE ranges from psychology and psychometric studies in humans, to neuropharmacology and toxicology, to molecular genetics of neurodevelopment and neurodegenerative disease in model organisms. Learn more >

Biomedical Engineering

Biomedical Engineering may be defined as the application of engineering principles to promote and enhance the health and well-being of humans. Applications span the gamut of clinical, therapeutic and diagnostic arenas. Research strengths of the GSBSE include; artificial muscle, biomedical microdevices and microsystems, Lab-on-Chip, Biosensors, nanodevices and instruments, cell mechanics, robotic surgery, single molecule imaging, spectroscopy and microscopy of biological materials, and porous implants for tissue ingrowth. Learn more >

Toxicology

Toxicology is an applied discipline that incorporates and builds on a host of scientific disciplines to investigate the consequences of exposure to chemical agents on living organisms and the environment, and the cellular and molecular mechanisms that underlie those consequences. Research strengths of the GSBSE include; comparative marine toxicology, chemical carcinogenesis, immunotoxicology, toxicogenomics, neurotoxicology, and outer space toxicology. Learn more >

Bioinformatics and Computational Biology

Research in bioinformatics and computational biology is an interdisciplinary area of study that brings together biologists, computer and information scientists, mathematicians, engineers, biophysicists, and chemists to examine fundamental biological processes through data intensive analysis and computational modeling.
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Harold Dowse

Harold Dowse

Contact Information

Phone:
(207) 581-2536

Email/web:
dowse@maine.edu
Download CV

Address:
School of Biology and Ecology
5751 Murray Hall 
Orono, ME  04469-5751

Education

Amherst College, BA; New York University, Ph.D.

Biosketch

I am interested in the cardiac pacemaker, specifically the calcium ion channels that underlie its oscillation.  I use genetics molecular biology and electrophysiology to unravel this problem in the Drosophila model system. 

Research Interests

In the Drosophila melanogaster system, I am investigating the intracellular calcium currents underlyling cellular oscillators, most prominently that of the cardiac pacemaker.  This involves looking at not just plasma membrane calcium channels and currents, but at the release and sequestration of calcium at the level of the sarcoplasmic reticulum and at the sodium/calcium exchanger.  The related oscillator that controls the male fly's mating song has proven informative, and we also are looking at this interesting process.  I use genetic, molecular and pharmacological tools in this investigation.

Selected Publications


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Our Programs

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We offer 3 degree programs in five research focus areas. Learn more


UMaine The Jackson Laboratory Maine Medical Center Research Institute The Mount Desert Island Biological Laboratory University of Southern Maine University of New England
 
For more information about the program, please contact:
Tammy Crosby • 207-581-4654 • gsbse@maine.edu