In Press

• Holmes, A.L. and Wise, Sr., J.P. Aneuploidy: Mechanisms, Cancer and the Role of Environmental Pollutants. In Anueploidy: Etiology, Disorders and Risk Factors. Eds: de Rossi, S. and Bianchi, F. Nova Publishers, In Press.

Additional Publications

• Wise, S.S., Holmes, A.L., Qin, Q., Xie, H., Katsifis, S., Thompson, W.D. and Wise, Sr., J.P. Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in Human Bronchial Cells. Chemical Research in Toxicology, 23(2): 365-372, 2010.
• Holmes, A.L., Wise, S.S., Pelsue, S.C., Aboueissa, A., Lingle, W., Salisbury, S., Gallaher, J. and Wise, Sr., J.P. Chronic Exposure to Zinc Chromate Induces Centrosome Amplification and Spindle Assembly Checkpoint Bypass in Human Lung Fibroblasts. Chemical Research in Toxicology, 23(2): 386-395, 2010.
• Wise, Sr., J.P., Wise, S.S., Holmes, A.L., LaCerte, C., Shaffiey, F., and Aboueissa, A. The Cytotoxicity and Genotoxicity of Hexavalent Chromium in Steller Sea Lion Lung Fibroblasts Compared to Human Lung Fibroblasts. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 152(1): 91-98, 2010.
• Holmes, A.L. and Wise, Sr., J.P. Mechanisms of Metal-Induced Centrosome Amplification. Biochemical Society Transactions, 38(6): 1687-1690, 2010.
• Xie, H., Holmes, A.L., Young, J.L., Qin, Q., Joyce, K, Pelsue, S.C., Peng, C., Wise, S.S., Jeevarajan, A., Wallace, W.T., Hammond, D. and Wise, Sr., J.P. Zinc Chromate Induces Chromosome Instability and DNA Double Strand Breaks in Human Lung Cells. Toxicology and Applied Pharmacology., 234: 293–299, 2009.
• Li Chen, T., Wise, S.S., Holmes, A., Shaffiey, F., Wise, Jr., J.P., Thompson, W.D., Kraus, S. and Wise, Sr., J.P. Cytotoxicity and genotoxicity of hexavalent chromium in human and North Atlantic right whale (Eubalaena glacialis) lung cells. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 150(4): 487-494, 2009.
• Wise, S.S., Holmes, A.L., Wise Sr., J.P. Hexavalent Chromium-Induced DNA Damage and Repair Mechanisms. Reviews on Environmental Health, 23(1): 39-57, 2008.
• Holmes, A.L., Wise, S.S., Wise Sr., J.P. The Carcinogenicity of Hexavalent Chromium. Indian Journal of Medical Research, 128: 353-372, 2008.
• Holmes, A.L., Wise, S.S., Goertz, C.E.C., Dunn, J.L., Gulland, F.M.D., Gelatt, T., Beckmen, K.B., Burek, K., Atkinson, S., Bozza, M., Taylor, R., Zheng, T., Zhang, Y., Aboueissa , A. and Wise, Sr., J.P. Metal Tissue Levels in Steller Sea Lion (Eumetopias jubatus) Pups. Marine Pollution Bulletin, 56(8): 1416-1421, 2008.
• Xie, H., Holmes, A.L., Wise, S.S., Huang, S., Peng, C., Wise Sr., J.P. Neoplastic Transformation of Human Bronchial Cells by Lead Chromate Particles. American Journal of Respiratory Cell and Molecular Biology, 37: 544-52, 2007.
• Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., Thompson, W.D., and Wise Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and Aneuploidy in Human Lung Cells. Cancer Research, 66(8): 4041-4048, 2006.
• Holmes, A.L., Wise, S.S., Sandwick, S.J., Wise Sr., J.P. Chronic Exposure to Lead Chromate Causes Persistent Chromosome Damage in Human Lung Cells. Mutation Research, 610:8-13, 2006.
• Wise, S.S., Holmes, A.L., Wise Sr., J.P. Particulate and Soluble Hexavalent Chromium Are Cytotoxic and Genotoxic to Human Lung Epithelial Cells. Mutation Research, 610:2-7, 2006.
• Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D., Wise Sr., J.P. Chronic Exposure to Particulate Chromate Induces Spindle Assembly Checkpoint Bypass in Human Lung Cells. Chemical Research in Toxicology, 19(11):1492-1498, 2006.
• Holmes, A.L., Wise, S. S., Xie, H., Gordon, N., Thompson W.D., and Wise Sr., J.P. Lead Ions Do Not Cause Human Lung Cells to Escape Chromate-Induced Cytotoxicity. Toxicology and Applied Pharmacology, 203:167-176, 2005.
• Xie, H., Wise, S.S., Holmes, A.L., Xu, B., Wakeman, T.P., Pelsue, S.C., Singh, N.P., Wise Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks in Human Lung Cells. Mutation Research, 586(2): 160-172, 2005.
• Wise, S.S., Holmes, A.L., Moreland, J.A., Xie, H., Sandwick, S.J., Stackpole, M.M., Fomenchenko, E.,Teufack, S., May Jr., A.J., Katsifis, S.P. and Wise Sr., J.P. Human Lung Cell Growth Is Not Stimulated By Lead Ions After Lead Chromate-Induced Genotoxicity. Molecular and Cellular Biochemistry, 279(1-2): 75-84, 2005.
• Wise, S.S., Schuler, J.H.C., Holmes, A.L., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Zheng T., and Wise Sr., J.P. A Comparison of Two Carcinogenic Particulate Hexavalent Chromium Compounds: Barium Chromate Is More Potent than Lead Chromate in Human Lung Cells. Environmental and Molecular Mutagenesis, 44:156-162, 2004.
• Xie, H., Holmes, A.L., Wise, S. S., Gordon, N., and Wise Sr., J.P.: Lead Chromate-Induced Chromosome Damage Requires Extracellular Dissolution to Liberate Chromium Ions but Does Not Require Particle Internalization or Intracellular Dissolution. Chemical Research in Toxicology, 17:1362-1367, 2004.
• Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsfis, S.P. and Wise Sr., J.P. Chromium is the Proximate Clastogenic Species for Lead Chromate-Induced Clastogenicity in Human Bronchial Cells. Mutation Research, 560:79-89, 2004.